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Using a Bayesian computational model, we estimate the likely range of model parameter values summarising contributions from contrast gain (which shifts the contrast response function laterally) and response gain (which scales it vertically). In this study we ask how we can characterise suppression from these different sources by examining the effect on the contrast response function (the function mapping the physical stimulus intensity to the neural response), measured using steady-state electroencephalography (EEG). In the visual system, there are multiple suppressive pathways, which normalize neural responses across dimensions such as spatial location, eye of origin, and feature (e.g. Suppression is a ubiquitous process in the brain that acts to regulate neural activity. Although suppression from different mask types involves distinct anatomical pathways, gain control processes appear to serve a common purpose, which we suggest might be to suppress less reliable inputs. At the second harmonic frequency (10Hz) suppression was stronger overall, and involved both contrast and response gain effects. Suppression generally became stronger at more lateral electrode sites, but there was little evidence of response gain effects. At the occipital pole, there was strong evidence for contrast gain effects in all four mask types at the first harmonic frequency (5Hz). We then conducted two new experiments, comparing suppression from four mask types (monocular and dichoptic overlay masks, and aligned and orthogonal surround masks) on responses to sine wave grating patches flickering at 5Hz. A computational meta-analysis of 16 previous studies found the most evidence for contrast gain effects with overlaid masks, but no clear evidence favouring either response gain or contrast gain for other mask types. We used a Bayesian hierarchical model to summarise the evidence for each type of gain control. Changes in contrast gain shift the contrast response function laterally, whereas changes in response gain scale the function vertically. We asked if these separate routes to suppression can be differentiated by their pattern of gain control on the contrast response function measured in human participants using steady-state electroencephalography. This includes features such as orientation (cross-orientation suppression), eye-of-origin (interocular suppression) and spatial location (surround suppression), which are thought to involve distinct anatomical pathways.
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In the early visual system, suppression occurs between neurons representing different stimulus properties.